Jiangsu Pacific minok bio Pharmaceutical Co., Ltd
  • Our research focus is identification of new tumor markers such as HAb18G/CD147 and subsequently creates humanized antibodies or fragments thereof enhancedby ADCC or ADC for precision targeting in tumor therapy.

    HAb18G/CD147 is a novel tumor marker screened from cDNA library of human hepatocellular carcinoma (HCC) tissues, belonging to the CD147 family, important in cancer proliferation and metastasis. CD147 is over expressed in multi-drug resistance (MDR) tumor cells.
    Zhi-Nan Chen, PhD, MD.
    Director and Professor of National Translational Science Center for Molecular Medicine
    Academician,Chinese Academy of Engineering.

    He first determined the crystal structure of the extracellular domain of HAb18G/CD147 as a new drug target in oncology.
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